@font-face {
  font-family: "Inter";
  font-style: normal;
  font-weight: 100 900;
  font-display: swap;
  src: url("../vendor/inter/inter-latin-wght-normal.260c81a4759b.woff2") format("woff2-variations");
}

:root {
  --hm-brand: #b4235a;
  --hm-brand-dark: #7d1540;
  --hm-brand-soft: #fbe7ef;
  --hm-ink: #1c2230;
  --hm-muted: #6b7385;
  --hm-line: #e7e9ef;
  --hm-bg: #f5f6fa;
  --hm-up: #d7263d;
  --hm-down: #1f6feb;
  --hm-ns: #9aa3b5;
  --bs-body-font-family: "Inter", system-ui, -apple-system, "Segoe UI", sans-serif;
  --bs-body-color: var(--hm-ink);
  --bs-body-bg: var(--hm-bg);
  --bs-primary: var(--hm-brand);
  --bs-primary-rgb: 180, 35, 90;
  --bs-link-color: var(--hm-brand);
  --bs-link-color-rgb: 180, 35, 90;
  --bs-link-hover-color: var(--hm-brand-dark);
  --bs-border-radius: .6rem;
  --bs-border-radius-lg: .9rem;
}

body { font-feature-settings: "cv11", "ss01"; -webkit-font-smoothing: antialiased; }
h1, h2, h3, h4, h5 { font-weight: 650; letter-spacing: -.015em; }
.text-muted { color: var(--hm-muted) !important; }
.fw-semibold { font-weight: 600 !important; }
.small-caps { text-transform: uppercase; font-size: .72rem; letter-spacing: .06em; font-weight: 600; color: var(--hm-muted); }

.btn-primary {
  --bs-btn-bg: var(--hm-brand); --bs-btn-border-color: var(--hm-brand);
  --bs-btn-hover-bg: var(--hm-brand-dark); --bs-btn-hover-border-color: var(--hm-brand-dark);
  --bs-btn-active-bg: var(--hm-brand-dark); --bs-btn-active-border-color: var(--hm-brand-dark);
  --bs-btn-disabled-bg: var(--hm-brand); --bs-btn-disabled-border-color: var(--hm-brand);
  font-weight: 550;
}
.btn-outline-primary {
  --bs-btn-color: var(--hm-brand); --bs-btn-border-color: var(--hm-brand);
  --bs-btn-hover-bg: var(--hm-brand); --bs-btn-hover-border-color: var(--hm-brand);
  --bs-btn-active-bg: var(--hm-brand-dark); --bs-btn-active-border-color: var(--hm-brand-dark);
}
.btn { font-weight: 550; }
.form-control:focus, .form-select:focus, .form-check-input:focus {
  border-color: #e38bab; box-shadow: 0 0 0 .2rem rgba(180, 35, 90, .15);
}
.form-check-input:checked { background-color: var(--hm-brand); border-color: var(--hm-brand); }
.form-switch .form-check-input:checked { background-color: var(--hm-brand); }

/* Navigation */
.hm-nav { background: #fff; border-bottom: 1px solid var(--hm-line); }
.hm-brand { display: flex; align-items: center; gap: .6rem; font-weight: 700; color: var(--hm-ink); text-decoration: none; letter-spacing: -.02em; }
.hm-brand:hover { color: var(--hm-ink); }
.hm-logo {
  width: 34px; height: 34px; border-radius: 10px; display: grid; place-items: center;
  background: linear-gradient(135deg, #e0457b, var(--hm-brand-dark)); color: #fff; font-size: 1.05rem;
  box-shadow: 0 4px 12px rgba(180, 35, 90, .3);
}
.hm-avatar {
  width: 32px; height: 32px; border-radius: 50%; display: inline-grid; place-items: center;
  background: var(--hm-brand-soft); color: var(--hm-brand); font-weight: 700; font-size: .85rem;
}

/* Cards */
.hm-card { background: #fff; border: 1px solid var(--hm-line); border-radius: var(--bs-border-radius-lg); box-shadow: 0 1px 2px rgba(20, 24, 40, .04); }
.hm-card-hover { transition: box-shadow .15s, transform .15s, border-color .15s; }
.hm-card-hover:hover { box-shadow: 0 8px 24px rgba(20, 24, 40, .08); transform: translateY(-1px); border-color: #d9dce6; }
.hm-stat { padding: 1rem 1.2rem; }
.hm-stat .value { font-size: 1.65rem; font-weight: 700; letter-spacing: -.02em; line-height: 1.1; }
.hm-stat .label { color: var(--hm-muted); font-size: .8rem; }
.hm-stat .icon { width: 38px; height: 38px; border-radius: 10px; display: grid; place-items: center; font-size: 1.1rem; }
.bg-up-soft { background: #fde8eb; color: var(--hm-up); }
.bg-down-soft { background: #e3eefe; color: var(--hm-down); }
.bg-brand-soft { background: var(--hm-brand-soft); color: var(--hm-brand); }
.bg-grey-soft { background: #eef0f5; color: #4b5366; }
.text-up { color: var(--hm-up) !important; }
.text-down { color: var(--hm-down) !important; }

.badge-up { background: #fde8eb; color: var(--hm-up); }
.badge-down { background: #e3eefe; color: var(--hm-down); }
.badge-ns { background: #eef0f5; color: #5c6477; }
.badge-na { background: #f5f5f5; color: #9aa0ab; }
.badge-org { background: #eef0f5; color: #3d4557; font-weight: 600; }

/* Login */
.hm-login { min-height: 100vh; display: grid; grid-template-columns: 1.1fr 1fr; }
.hm-login-art {
  position: relative; overflow: hidden; color: #fff; padding: 3rem;
  background: radial-gradient(1200px 600px at 10% 10%, #e0457b 0%, transparent 60%),
              radial-gradient(900px 700px at 90% 90%, #3b1e6e 0%, transparent 60%), #7d1540;
  display: flex; flex-direction: column; justify-content: space-between;
}
.hm-login-art svg { position: absolute; inset: 0; width: 100%; height: 100%; opacity: .22; }
.hm-login-art > * { position: relative; }
.hm-login-form { display: grid; place-items: center; padding: 2rem; background: #fff; }
.hm-login-form form { width: 100%; max-width: 380px; }
@media (max-width: 900px) { .hm-login { grid-template-columns: 1fr; } .hm-login-art { display: none; } }

/* Stepper */
.hm-steps { display: flex; gap: .5rem; align-items: center; font-size: .85rem; color: var(--hm-muted); }
.hm-steps .step { display: flex; align-items: center; gap: .45rem; }
.hm-steps .dot { width: 24px; height: 24px; border-radius: 50%; display: grid; place-items: center; font-weight: 700; font-size: .75rem; background: #e7e9ef; color: #6b7385; }
.hm-steps .active .dot { background: var(--hm-brand); color: #fff; }
.hm-steps .done .dot { background: #d5f2e3; color: #178a50; }
.hm-steps .active { color: var(--hm-ink); font-weight: 600; }
.hm-steps .sep { flex: 0 0 28px; height: 1px; background: #d7dae3; }

/* Upload */
.hm-drop {
  border: 2px dashed #d3d7e2; border-radius: var(--bs-border-radius-lg); background: #fafbfd;
  padding: 2.2rem 1rem; text-align: center; cursor: pointer; transition: border-color .15s, background .15s;
}
.hm-drop:hover, .hm-drop.dragover { border-color: var(--hm-brand); background: var(--hm-brand-soft); }
.hm-drop .bi { font-size: 2.2rem; color: var(--hm-brand); }
.hm-drop input[type=file] { display: none; }

.hm-choice input { display: none; }
.hm-choice label {
  display: flex; gap: .8rem; align-items: center; padding: .9rem 1rem; border: 1.5px solid var(--hm-line);
  border-radius: var(--bs-border-radius-lg); cursor: pointer; background: #fff; transition: border-color .15s, background .15s;
}
.hm-choice input:checked + label { border-color: var(--hm-brand); background: var(--hm-brand-soft); }
.hm-choice .emoji { font-size: 1.6rem; }

/* Column roles */
.hm-roles { display: grid; grid-template-columns: repeat(auto-fill, minmax(210px, 1fr)); gap: .6rem; }
.hm-role { border: 1px solid var(--hm-line); border-radius: .7rem; padding: .55rem .7rem; background: #fff; display: flex; align-items: center; justify-content: space-between; gap: .5rem; }
.hm-role.role-a { border-color: #f0b6c9; background: #fff6f9; }
.hm-role.role-b { border-color: #b9cff7; background: #f5f8ff; }
.hm-role .name { font-weight: 600; font-size: .85rem; overflow: hidden; text-overflow: ellipsis; white-space: nowrap; }
.hm-seg { display: inline-flex; background: #eef0f5; border-radius: .5rem; padding: 2px; flex: none; }
.hm-seg input { display: none; }
.hm-seg label { padding: .15rem .55rem; border-radius: .4rem; font-size: .78rem; font-weight: 700; cursor: pointer; color: #6b7385; }
.hm-seg input[value=a]:checked + label { background: var(--hm-brand); color: #fff; }
.hm-seg input[value=b]:checked + label { background: var(--hm-down); color: #fff; }
.hm-seg input[value=x]:checked + label { background: #fff; color: var(--hm-ink); box-shadow: 0 1px 2px rgba(0, 0, 0, .1); }
.chip-a { background: var(--hm-brand); color: #fff; }
.chip-b { background: var(--hm-down); color: #fff; }

.hm-preview { font-size: .8rem; }
.hm-preview th { white-space: nowrap; font-weight: 600; background: #f7f8fb; position: sticky; top: 0; }
.hm-preview th.col-a { background: #fde8ef; color: var(--hm-brand-dark); }
.hm-preview th.col-b { background: #e3eefe; color: #154fa8; }
.hm-preview th.col-id { background: #fff4d6; color: #7a5a00; }
.hm-preview td { white-space: nowrap; max-width: 220px; overflow: hidden; text-overflow: ellipsis; }

/* Results */
.hm-toolbar { display: flex; flex-wrap: wrap; gap: .75rem 1.25rem; align-items: center; padding: .7rem 1rem; }
.hm-toolbar .form-select, .hm-toolbar .form-control { width: auto; }
.nav-hm { gap: .25rem; border-bottom: 1px solid var(--hm-line); }
.nav-hm .nav-link { color: var(--hm-muted); font-weight: 600; border: 0; border-bottom: 2px solid transparent; border-radius: 0; padding: .7rem 1rem; }
.nav-hm .nav-link:hover { color: var(--hm-ink); }
.nav-hm .nav-link.active { color: var(--hm-brand); border-bottom-color: var(--hm-brand); background: none; }

.hm-map-wrap { position: relative; height: calc(100vh - 250px); min-height: 520px; background: #fff; border-radius: 0 0 var(--bs-border-radius-lg) var(--bs-border-radius-lg); overflow: hidden; }
.hm-map-wrap canvas { position: absolute; inset: 0; width: 100%; height: 100%; cursor: grab; touch-action: none; }
.hm-map-wrap canvas.dragging { cursor: grabbing; }
.hm-map-wrap canvas.pointer { cursor: pointer; }
.hm-map-tools { position: absolute; top: .8rem; left: .8rem; display: flex; gap: .5rem; flex-wrap: wrap; z-index: 2; max-width: calc(100% - 1.6rem); }
.hm-map-tools .form-control, .hm-map-tools .form-select { box-shadow: 0 2px 8px rgba(20, 24, 40, .08); }
.hm-map-zoom { position: absolute; right: .8rem; top: .8rem; display: flex; flex-direction: column; gap: .35rem; z-index: 2; }
.hm-map-zoom .btn { width: 36px; height: 36px; padding: 0; display: grid; place-items: center; background: #fff; border: 1px solid var(--hm-line); box-shadow: 0 2px 8px rgba(20, 24, 40, .08); }
.hm-legend { position: absolute; left: .8rem; bottom: .8rem; background: rgba(255, 255, 255, .94); border: 1px solid var(--hm-line); border-radius: .7rem; padding: .6rem .8rem; font-size: .75rem; z-index: 2; box-shadow: 0 2px 8px rgba(20, 24, 40, .06); }
.hm-legend .bar { width: 180px; height: 10px; border-radius: 5px; background: linear-gradient(90deg, #1f6feb, #9ec1fa, #f0f0f0, #f5a3ad, #d7263d); }
.hm-legend .swatch { display: inline-block; width: 18px; height: 4px; border-radius: 2px; vertical-align: middle; margin-right: .3rem; }
.hm-tooltip { position: absolute; pointer-events: none; z-index: 5; background: #1c2230; color: #fff; border-radius: .55rem; padding: .5rem .7rem; font-size: .78rem; max-width: 320px; box-shadow: 0 6px 20px rgba(0, 0, 0, .2); display: none; }
.hm-tooltip .fc-up { color: #ff8a98; }
.hm-tooltip .fc-down { color: #8db8ff; }
.hm-map-loading { position: absolute; inset: 0; display: grid; place-items: center; color: var(--hm-muted); z-index: 1; }

.hm-panel { width: 420px !important; }
.hm-panel .gene-title { font-size: 1.35rem; font-weight: 700; letter-spacing: -.02em; }
.hm-kv { display: grid; grid-template-columns: 1fr 1fr; gap: .6rem; }
.hm-kv > div { background: #f7f8fb; border-radius: .6rem; padding: .55rem .7rem; }
.hm-kv .k { font-size: .72rem; color: var(--hm-muted); }
.hm-kv .v { font-weight: 650; font-variant-numeric: tabular-nums; }

.hm-plot { height: calc(100vh - 250px); min-height: 520px; }
.tabulator { font-size: .82rem; border: 0; background: #fff; }
.tabulator .tabulator-header { border-bottom: 1px solid var(--hm-line); background: #f7f8fb; }
.tabulator .tabulator-header .tabulator-col { background: #f7f8fb; }
.tabulator-row.tabulator-selectable:hover { background: #fbf3f6; cursor: pointer; }
.fc-bar { display: flex; align-items: center; gap: .4rem; font-variant-numeric: tabular-nums; }
.fc-bar .track { position: relative; width: 60px; height: 6px; background: #eef0f5; border-radius: 3px; flex: none; }
.fc-bar .fill { position: absolute; top: 0; height: 6px; border-radius: 3px; }
.num { font-variant-numeric: tabular-nums; }

.hm-methods { max-width: 820px; line-height: 1.65; }
.hm-methods code { color: var(--hm-brand-dark); background: var(--hm-brand-soft); padding: .1rem .35rem; border-radius: .3rem; }

.table-hm { --bs-table-bg: transparent; font-size: .88rem; }
.table-hm thead th { font-size: .72rem; text-transform: uppercase; letter-spacing: .05em; color: var(--hm-muted); font-weight: 600; border-bottom-color: var(--hm-line); }
.table-hm td { border-color: var(--hm-line); vertical-align: middle; }
.table-hm tbody tr.clickable { cursor: pointer; }
.table-hm tbody tr.clickable:hover { background: #fbf3f6; }

.empty-state { text-align: center; padding: 4rem 1rem; }
.empty-state .bi { font-size: 3rem; color: #d3a1b5; }